Track-Before-Detect Filter Banks for Noise Object Tracking

The Track-Before-Detect (TBD) filter banks is proposed for the processing of noise object that are additive to the background noise. Spatio-Temporal TBD algorithm uses the preprocessing of measurement. The modified moving standard deviation filter is applied. The correction of the results for the selection of the highest possible filter banks window is proposed. Position and velocity errors are evaluated numerically for two smoothing coefficients. Monte Carlo test shows that all filter banks allow the tracking if the standard deviation of the background is below 1.3

Wodoodporność recyklowanej podbudowy z asfaltem spienionym w aspekcie składu spoiwa drogowego

The paper describes research results of recycled base which was performedin a cold deep recycling technology with foamed bitumen and different type of hydraulicmixed binder in the aspect of water resistance. An individual design of a composition of abinder enables to achieve a precise adjustment of a binder’s impact to local conditions andrequired parameters of a recycled base. The design a recycled base with foamed bitumensimulated a cold deep recycling process with materials from existing crushed bituminouspavement layers ("technology in-situ"). To produce the foamed bitumen a road bitumen ofpenetration grade 50/70 was used. Moreover, the following mineral components werecategorised as a waste material: reclaimed asphalt pavement, 0/31,5 mm aggregate andaggregates for soil gradation improvement 0/4. A composition of the recycled base consisted of the binders prepared in the laboratory as a result of a mix of three basic components.The percentage of individual road binders was determined in line with the plan of thesimlex-centroid experiment. For the purpose of determining an influence of such a hydraulicroad binder on the water resistance in recycled base, the following tests were carried out:void contents Vm, tensile strength ratio TSR (water resistance). Additionally, an evaluationof increase of indirect tensile modulus (IT-CY) was conducted. On the basis of the testresults, a varied impacts of tested hydraulic road binders on mechanical properties andwater resistence of recycled base with foamed bitumen were observed. On the basis of theplan of the experiment, it was possible to determine the recommended road binder composition that enabled to obtain the water resistance in the recycled base with foamed bitumenW referacie przedstawiono rezultaty badań recyklowanej podbudowywykonanej w technologii recyklingu głębokiego na zimno z asfaltem spienionym orazspoiwem mieszanym. W badaniach szczególną uwagę zwrócono na jej wodoodporność.Indywidualne projektowanie składu spoiwa pozwala na precyzyjne dostosowanie jegooddziaływania do warunków terenowych oraz wymaganych parametrów recyklowanejpodbudowy. Projekt recyklowanej podbudowy z asfaltem spienionym symulował procesrecyklingu głębokiego na zimno. Zastosowane składniki mineralne tj. destrukt asfaltowy,kruszywo 0/31,5 mm oraz kruszywo doziarniające 0/4 stanowiły materiał odpadowyz istniejącej konstrukcji. W składzie recyklowanej podbudowy zastosowano spoiwa drogowe, które wytworzono w warunkach laboratoryjnych z wymieszania trzech bazowychskładników. Udział procentowy poszczególnych spoiw drogowych określono zgodnychz planem eksperymentu sympleksowo-centroidowego. Na podstawie uzyskanych wynikówbadań stwierdzono różnorodny wpływ analizowanych składników spoiw drogowych nawłaściwości mechaniczne oraz wodoodporność recyklowanej podbudowy. W oparciuo zastosowany plan eksperymentu możliwe było określenie składu spoiwa drogowego, którezapewni uzyskanie recyklowanej podbudowy odpornej na działanie wody

Buckling deformation of thin layer coverings of small curvatures used in aircraft construction

This paper presents the results of the experimental and numerical analysis in terms of the finite element method of plating components of aircraft load-bearing structures. The subject matter of the study was composite panels with stiffeners in the form of a regular grid of oriented longitudinal elements in accordance with the directions of the principal stresses in the covering. The analysis was conducted in the buckling states of structural deformation which showed that structures with stiffeners exhibit much more favorable behavior in buckling deformation states than in laminar structures.This translates into stress distributions and their gradients, which are milder in forms of stiffened structures

Potential mechanism of action of cyclosporin a in human dermal fibroblasts—Transcriptomic analysis of CYPs

Effect of cyclosporin A (CsA) in a therapeutic concentration, on the expression of cytochrome P450 genes (CYPs), was investigated in normal human dermal fibroblast cells. The expression of 57 genes, encoding cytochrome P450 isoforms, was estimated using the microarray method. Amongst 396 normalized fluorescence signals related to cytochrome P450 activity, only 91 were strictly connected to CYPs and were analyzed using two methods: a self-organizing feature map of artificial neural networks and typical statistical analysis with significance level at p ≤ 0.05. Comparing the samples from fibroblasts cultured with CsA and those cultured without, up-regulated changes of CYP19A1, 1B1, 7A1, 7F1, 17A1 and down-regulated 2D6 gene expression were observed. The mRNAs with increased changes were in the same neuron of the self-organizing feature map. All distinguished CYPs encode monooxygenases, which plays an important role in steroids biosynthesis and metabolism. Based on the obtained results, we can conclude that CsA in therapeutic concentration changes the expression profile of CYPs in human dermal fibroblasts, especially affecting genes linked to steroids synthesis and/or metabolism. It shows the potential mechanism of action of CsA in human dermal fibroblast cell

The diagnostic efficacy and safety of stress-only supine and prone myocardial perfusion imaging with a dedicated cardiac gamma camera in patients with suspected or known coronary artery disease

BACKGROUND: Myocardial perfusion scintigraphy remains one of the substantial noninvasive diagnostic methods in coronary artery disease. Recent technological advancement allowed to create novel semiconductor, dedicated cardiac gamma camera with better spatial resolution and higher energy resolution, resulting in the reduction of radiation burden and acquisition time. The aim of this study was to evaluate the efficacy and safety of stress-only supine and prone MPS with a cardiac gamma camera in patients with suspected or known coronary artery disease. MATERIAL AND METHODS: A total number of 203 consecutive patients with suspected or known coronary artery disease, who underwent MPS were enrolled in the study. The patients without perfusion abnormalities on stress supine and prone MPS scans had no rest MPS, in the remaining patients two-day stress-rest imaging was performed. The group of 160 patients with one-year follow up was subjected to final analysis. RESULTS: Stress-only protocol of myocardial perfusion imaging was performed in 72 patients, 88 patients underwent two-day stress and rest myocardial perfusion scintigraphy. In 46 out of 72 stress-only group of patients, prone study did not affect further proceedings. However, in over 1/3 of cases (26/72), prone scans resulted in abstaining from rest imaging. One year follow-up revealed no sudden cardiac deaths or myocardial infarctions in both (stress-only and stress-rest) groups. Revascularization was performed most often in the double-positive group — patients with significant ischaemia on myocardial perfusion images and chest pain or electrocardiographic changes or both during the stress test. In this double-positive group, all 11 patients had coronary angiography (two of them prior to myocardial perfusion scintigraphy), nine of them had subsequent revascularization. CONCLUSIONS: In patients with no significant perfusion abnormalities on stress scans omitting rest study is safe with very good one-year risk prognosis of acute cardiac events and allows to limit the radiation exposure and procedure duration. Additional prone acquisitions are valuable supplements in determining the decision of safe early completion of myocardial perfusion imaging

Infertility - causes, diagnosis, preventive measures and methods of treatment

The problem of infertility affects approximately 20% of married couples, and the number of people affected by this problem is still increasing[5,6]. Developed countries are characterized by the prevalence of primary infertility, while in developing countries there is a high rate of secondary infertility[8,9]. The most common cause of marital infertility is obstruction of the fallopian tubes, which occurs in 30-35% of women and requires surgical intervention. However, both sexes are dominated by immunological and hormonal disorders (25%-30% of cases)[3,4]. The basic examination in which male fertility is determined is the semen analysis, while in women, many tests should be performed in order to make a diagnosis: anamnesis, gynecological examination, ultrasound performed repeatedly during the menstrual cycle (ovulation assessment), hormonal and immunological tests, post-coital tests, bacteriological cultures, hysterosalpingography or laparoscopy [20]. In vitro fertilization is the most effective of all methods of infertility treatment. In vitro fertilization can be performed using the classical method by adding prepared sperm to the egg cells or by microinjection of the sperm into the egg cell[21]